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Synthesis of 21-diazoprogesterone-6,7-3H2

✍ Scribed by Wen-Hsiung Chiu; Manfred E. Wolff

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
354 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The preparation of 21‐diazoprogesterone‐6,7‐^3^H~2~ is described. Progesterone was dehydrogenated with chloranil to give Δ^6^‐dehydroprogesterone. Degradation of the pregnane side‐chain with sodium hypobromite gave the corresponding carboxylic acid. Catalytic reduction with carrier‐free tritium followed by treatment with oxalyl chloride and then diazomethane afforded 21‐diazoprOgesterone‐6,7‐^3^H~2~ with a specific activity of 42 Ci/mmol.

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