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Synthesis of [14C]imidazole ring labeled metiamide, cimetidine and impromidine

✍ Scribed by A. J. Villani; L. Petka; D. W. Blackburn; D. Saunders; G. R. White; J. Winster

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
364 KB
Volume
27
Category
Article
ISSN
0022-2135

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✦ Synopsis

The radiosynthesis of imidazole ring labeled [14c]metiamide, [1k]cimetidine and ["k]impromidine are described involving the reaction of the key common intexmediate 2-[[(4methyl-lH-[2-14C]imidazol-5-yl)methyl]thio]ethanamine @ w i t h methyl isothiocyanate, dimethyldithiocyanoiminocarbonate/methylamine and the novel dihydroknidazdiazepine 0, res ectively. The ring labeled precursor @ was prepared in five steps from potassium mCi/mmol.

[ 1 B Clcyanide in an overall radiochemical yield of 63%, and having a specific activity of 9.3

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