✦ LIBER ✦

Synthesis of [14C]-N-[(trimethylamineboryl) carbonyl]-phenylalanine-methyl ester

✍ Scribed by Merrill C. Miller; Steven D. Wyrick; Iris H. Hall; Anup Sood; Bernard F. Spielvogel

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 166 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310805

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Reported is the synthesis of [^14^C]‐L‐N‐[(trimethylamineboryl)carbonyl]‐phenylalanine methyl ester, a boron containing α‐amino acid dipeptide analog with anti‐neoplastic, anti‐inflammatory, and hypolipidemic activities. The ^14^C label is universally distributed among all carbon positions of the phenylalanine portion of the molecule. Briefly, the dipeptide is prepared by reacting the phenylalanine methyl ester hydrochloride salt with trimethylamine‐carboxyborane, triphenylphospine (TPP), CCl~4~, and triethylamine (TEA) in acetonitrile, for 24 hours. The final product afforded a specific activity of 5.71 mCi/mmol.

📜 SIMILAR VOLUMES

N-Allyl-N-(2-nitrobenzenesulfonyl)-l-p

N-Allyl-N-(2-nitrobenzenesulfonyl)-l-phenylalanine methyl ester

✍ Poulsen, Sally-Ann ;Noack, Cassandra L. ;Healy, Peter C. 📂 Article 📅 2003 🏛 International Union of Crystallography 🌐 English ⚖ 200 KB

Single-crystal X-ray study T = 295 K Mean '(C±C) = 0.006 A Ê R factor = 0.040 wR factor = 0.123 Data-to-parameter ratio = 11.0 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.

N-Phthaloyl-l-alanyl-l-phenylalanine me

N-Phthaloyl-l-alanyl-l-phenylalanine methyl ester

✍ Hayman, Alan R. ;Simpson, Jim 📂 Article 📅 2002 🏛 International Union of Crystallography 🌐 English ⚖ 280 KB

Synthesis of [Carbonyl-14c] labeled carb

Synthesis of [Carbonyl-14c] labeled carbonate and carbamate esters

✍ Munir N. Nassar; Bushra J. Agha; George A. Digenis 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 344 KB

A two-step s y n t h e s i s of t h r e e carbonate and f o u r carbamate esters l a b e l e d a t t h e carbonyl with c a r n-14 i s described. The method u t i l i z e s t h e r e a d i l y a v a i l a b l e [' %I -phosgene which i s f i r s t converted t o an i s o l a b l e [14C] -labeled a l k

Synthesis of [methyl-14C]-N-methylputres

Synthesis of [methyl-14C]-N-methylputrescine

✍ H. V. Secor; R. R. Izac; S. B. Hassam; A. F. Frisch 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 272 KB 👁 1 views

## Abstract [Methyl‐^14^C]‐N‐methylputrescine was prepared from [^14^C]methylamine hydrochloride in five steps. Reaction of benzaldehyde and [^14^C]methylamine (10 mCi) followed by catalytic hydrogenation yielded [methyl‐^14^C]‐N‐methylbenzylamine. The key step in this process is the alkylation of

Synthesis of tropine-labeled atropine II

Synthesis of tropine-labeled atropine III. Synthesis of N-methyl-14C-tropine and N-methyl-14C-atropine

✍ Gilbert C. Schmidt; Thomas E. Eling; John M. McOwen 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 499 KB 👁 1 views

Synthesis of 1-carboxy-N, N, N-tri-[meth

Synthesis of 1-carboxy-N, N, N-tri-[methyl-14C] methanaminium chloride (betaine [methyl-14C] hydrochloride)

✍ S. Goszczynski; R.L. Crawford 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 194 KB 👁 2 views

Methyl bromoacetate was reacted with trimethyla~nine-[~'C] dissolved in methanol, forming the methyl ester of [I4C] labeled betaine hydrobromide. The methyl ester was hydrolyzed in an alkaline medium to (carboxymethy1)trimethylammonium hydroxide inner salt, and then transformed into the hydrochlorid