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Synthesis of 14C-labelled 1-(2,6-dimethyphenylamino)-2-dimethylamino-propane

✍ Scribed by G. Zólyomi; Z. Zubovics; L. Toldy

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
245 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

The antiarrhytmic 1-(2,6-dimethylphenylamin0)-2--dimethylamino-propane (&) was labelled with I4C for pharmacokinetic study. A convenient synthesis, using 2-brom0propionyl-l-~~C chloride as radioactive key intermediate, involving an improved method for the reduction of N-( 2-dimethylaminopropionyl)-2,6--dimethylaniline (8) was elaborated.

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