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Synthesis of 14C-labeled copolymers for drug delivery studies

✍ Scribed by Sung W. Rhee; Elmer J. Reist; Marie T. Rock

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
315 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^14^C‐labeled polyanhydride copolymers [(20:80/1,3‐bis)(p‐carboxyphenoxy)‐propane(CPP):sebacic acid (SA)] (7 and 13) were synthesized according to schemes I and II: ^14^C‐labeled sebacic acid (2,9‐^14^C~2~) (5) and ^14^C‐labeled CPP 1,3‐bis(p‐carboxyphenoxy)‐propane (labeled at C‐1, C‐3 of the propyl group) (11) were transformed to the corresponding mixed anhydrides (6 and 12) as prepolymers respectively by reaction with acetic anhydride. The labeled mixed anhydride prepolymers (6 and 12) were condensed with unlabeled counter‐prepolymers (12′ and 6′) to give the labeled polyanhydride copolymers (7 and 13). The labeled copolymers (7 and 13) were identified and characterized by gel permeation chromatography (GPC).

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