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Synthesis of [14C]- and [35S]-labelled PI-88 for pharmacokinetic and tissue distribution studies

✍ Scribed by Vito Ferro; Caiping Li; Bin Wang; Kym Fewings; Andrew R. King; Edward Hammond; Brian R. Creese

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
96 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

PI‐88, uniformly labelled with [^14^C] was prepared by incorporating D‐[^14^C]glucose into the fermentation of Pichia (Hansenula) holstii NRRL Y‐2448 under controlled conditions to produce [^14^C]‐labelled extracellular phosphomannan. Subsequent acid catalyzed hydrolysis gave the [^14^C]‐labelled oligosaccharide phosphate fraction which was sulfonated with excess sulfur trioxide pyridine complex to give [^14^C]PI‐88. [^35^S]‐labelled PI‐88 was similarly prepared by the sulfonation of unlabelled oligosaccharide phosphate fraction with [^35^S] sulfur trioxide pyridine complex. Copyright © 2002 John Wiley & Sons, Ltd.

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