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Synthesis of 11C-labelled acamprosate for PET studies

✍ Scribed by Jan Courtyn; Patrick Goethals; Johan Van der Eycken; Richard Dams

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
104 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A method for labelling acamprosate (calcium N‐acetyl homotaurinate), an anti‐craving compound for ethanol, with ^11^C, has been developed for in vivo studies with positron emission tomography (PET). The synthesis was based on the acylation of homotaurinate using [^11^C]acetyl chloride as the labelling agent. Reversed‐phase HPLC in highly aqueous mobile phase conditions was used for product purification. The radiochemical yield achieved was about 1.14 GBq (31 mCi) with a specific radioactivity of 8.14 GBq/µmol (220 mCi/µmol). For the identification of ^11^C‐radioactivity and determination of specific radioactivities, HPLC and ^1^H‐NMR were used. Copyright © 2001 John Wiley & Sons, Ltd.

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