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Synthesis of 14C and 3H labelled 6-nitro-7-sulfamoylbenzo[f]quinoxalin-2,3-dione

✍ Scribed by Christian Foged; Poul Jacobsen

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
288 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A ^14^C labelled form of 6‐nitro‐7‐sulfamoylbenzo[f]quinoxalin‐2,3‐dione [1] was synthesized in two steps from 1,2‐diamino‐5‐sulfamoylnaphthalene [2] and 30 mCi ^14^C‐oxalic acid. A total of 5.5 mCi was isolated as a yellow solid with a radiochemical purity > 99%. The specific activity was 99 mCi/mmol.

A ^3^H labelled form of [1] was synthesized in two steps from 10‐bromo‐7‐sulfamoylbenzo‐[f]quinoxalin‐2,3‐dione [4] and tritium gas. The product was isolated with a radiochemical purity of >98% and a specific activity of 10 Ci/mmol.

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