Synthesis of 11C-radiopharmaceuticals using direct fixation of [11C]carbon dioxide and [11C]carbon monoxide
β Scribed by Ram, Siya; Lee Ehrenkaufer, Richard
- Book ID
- 123570195
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 987 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0883-2897
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Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.