The synthesis of 8-methyl-PGC22 and 12-methyl-PGAa3 and -PGE24 has been described recently. Degradation to biological inactive PGB-derivatives 1s lmpossible in these compounds. We now wish to report the synthesis of the lO,lO-dimethyl-PGEl analog A, which cannot be deactivated easily by transformat
Synthesis of 10,10-dimethylprostaglandins
β Scribed by O.G. Plantema; H. de Koning; H.O. Huisman
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 182 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract [10,10,10β^2^H~3~]β3, 7βDimethylβ2(E), 6βoctadienyl diphosphate ([10,10,10β^2^H~3~]geranyl diphosphate) was synthesized from 6β(benzyloxy)β4βmethylβ4(E)βhexenal by regioselective deuteration involving a modified Wittig reaction as the key step.
lo-Azaprostaglandin (succinimide) analogues (la, b, c) were synthesised in a stereospecific manner from readily available materials. In the search for therapeutically useful synthetic prostaglandins, heterocyclic analogues have received considerable attenti0n.l This laboratory2 and others3 have rece