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Synthesis of 10,10-dimethylprostaglandins

✍ Scribed by O.G. Plantema; H. de Koning; H.O. Huisman


Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
182 KB
Volume
16
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Synthesis of 10,10-dimethylprostaglandin
✍ O.G. Plantema; H. de Koning; H.O. Huisman πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science 🌐 French βš– 185 KB

The synthesis of 8-methyl-PGC22 and 12-methyl-PGAa3 and -PGE24 has been described recently. Degradation to biological inactive PGB-derivatives 1s lmpossible in these compounds. We now wish to report the synthesis of the lO,lO-dimethyl-PGEl analog A, which cannot be deactivated easily by transformat

Synthesis of [10,10,10-2H3]geranyl dipho
✍ Shunsuke Izumi; Mie Aihara; Yoshikazu Hiraga; Toshifumi Hirata; Takayuki Suga πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 251 KB

## Abstract [10,10,10‐^2^H~3~]‐3, 7‐Dimethyl‐2(E), 6‐octadienyl diphosphate ([10,10,10‐^2^H~3~]geranyl diphosphate) was synthesized from 6‐(benzyloxy)‐4‐methyl‐4(E)‐hexenal by regioselective deuteration involving a modified Wittig reaction as the key step.

Synthesis of 10-azaprostaglandins
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lo-Azaprostaglandin (succinimide) analogues (la, b, c) were synthesised in a stereospecific manner from readily available materials. In the search for therapeutically useful synthetic prostaglandins, heterocyclic analogues have received considerable attenti0n.l This laboratory2 and others3 have rece