Multiply labelled d 8 -geranyl diphosphate (3-methyl-7-2 H 3 -methyl-[1,1,8,8,8]-2 H 5 -2E,6-octadienyl diphosphate) was synthesised from geraniol in 8 steps. Geraniol was converted to [1,1]-2 H 2 -geraniol by a three step oxidation-reduction sequence in 38% yield. Selective epoxidation of [1,1]-2 H
Synthesis of [10,10,10-2H3]geranyl diphosphate
โ Scribed by Shunsuke Izumi; Mie Aihara; Yoshikazu Hiraga; Toshifumi Hirata; Takayuki Suga
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 251 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
Abstract
[10,10,10โ^2^H~3~]โ3, 7โDimethylโ2(E), 6โoctadienyl diphosphate ([10,10,10โ^2^H~3~]geranyl diphosphate) was synthesized from 6โ(benzyloxy)โ4โmethylโ4(E)โhexenal by regioselective deuteration involving a modified Wittig reaction as the key step.
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Samples of racemic [10-3H] juvenile hormone 111 (methyl (2~,6~)-lO,ll-epoxy-3,7,11-trimethyl-2,6-dodecadienoate) and [lo-3 Hljuvenile hormone 0 (methyl (2E,6~,10~)-3,7-diethyl-l0,1l-epoxy-ll-methyl-2,6-tridecadienoate~were prepared by NaB H4 reduction of the corresponding 1 I-chloro-lo-oxo ("chlorok
## Abstract Cyclocondensation of 2,3,3โtrimefhylโ3__H__โindoles **2** with malonates **3** gives 8โhydroxyโ10,10โdimefhylโ10__H__โpyrido[1,2โ__a__]indolโ6โones **4**, which were halogenated in position 7, 8 and 9 with sulfuryl chloride, bromine or phosphoroxychloride to give the corresponding haloโ
## Abstract For Abstract see ChemInform Abstract in Full Text.