Synthesis of 10,10-dimethylprostaglandin
โ
O.G. Plantema; H. de Koning; H.O. Huisman
๐
Article
๐
1975
๐
Elsevier Science
๐
French
โ 185 KB
The synthesis of 8-methyl-PGC22 and 12-methyl-PGAa3 and -PGE24 has been described recently. Degradation to biological inactive PGB-derivatives 1s lmpossible in these compounds. We now wish to report the synthesis of the lO,lO-dimethyl-PGEl analog A, which cannot be deactivated easily by transformat