๐”– Bobbio Scriptorium
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Synthesis of 10-azaprostaglandin E1

โœ Scribed by P.A. Zoretic; F. Barcelos


Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
208 KB
Volume
18
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of 8-azaprostaglandin E1 and E
โœ J.W. Bruin; H. de Koning; H.O. Huisman ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 162 KB
Synthesis of 10-azaprostaglandins
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lo-Azaprostaglandin (succinimide) analogues (la, b, c) were synthesised in a stereospecific manner from readily available materials. In the search for therapeutically useful synthetic prostaglandins, heterocyclic analogues have received considerable attenti0n.l This laboratory2 and others3 have rece

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The synthesis of 8-methyl-PGC22 and 12-methyl-PGAa3 and -PGE24 has been described recently. Degradation to biological inactive PGB-derivatives 1s lmpossible in these compounds. We now wish to report the synthesis of the lO,lO-dimethyl-PGEl analog A, which cannot be deactivated easily by transformat

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Resolvin E1 (RvE1), which is an endogenous mediator to resolve inflammation, was synthesized by Wittig reaction between the C15-C20 aldehyde and the C10-C14 phosphonium salt possessing the vinyl iodo moiety followed by Suzuki-Miyaura coupling of the resulting vinyl iodide with the vinyl borane of th