✦ LIBER ✦

Synthesis of 10-azaprostaglandins

✍ Scribed by Richard W. King

Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 203 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)90566-0

No coin nor oath required. For personal study only.

✦ Synopsis

lo-Azaprostaglandin (succinimide) analogues (la, b, c) were synthesised in a stereospecific manner from readily available materials. In the search for therapeutically useful synthetic prostaglandins, heterocyclic analogues have received considerable attenti0n.l This laboratory2 and others3 have recently reported the potent and diverse biological activities exhibited by the 10,12diazaprostaglandins. Continuing our interest in this area we now describe the synthesis of lo-azaprostaglandin (succinimide) analogues (la, b, c).~

📜 SIMILAR VOLUMES

Synthesis of 10-azaprostaglandin E1

✍ P.A. Zoretic; F. Barcelos 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 208 KB

Synthesis of 11-desoxy-8-azaprostaglandi

Synthesis of 11-desoxy-8-azaprostaglandin E1

✍ George Bolliger; Joseph M. Muchowski 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 164 KB

Synthesis of 8-azaprostaglandin E1 and E

Synthesis of 8-azaprostaglandin E1 and E2

✍ J.W. Bruin; H. de Koning; H.O. Huisman 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 162 KB

A simple approach to 12-azaprostaglandin

A simple approach to 12-azaprostaglandin congeners

✍ J. C. Lapierre Armande; U. K. Pandit 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 535 KB

## Abstract The base‐catalyzed alkylation of __N__‐acylated 3‐pyrrolines has been studied. The reaction has been utilized in an approach to the synthesis of 12‐azaprostaglandins according to the following sequence. 3‐Pyrroline was acylated with 1‐chloro‐1‐octen‐3‐one and the resulting amide alkylat

Synthesis of 10,10-dimethylprostaglandin

Synthesis of 10,10-dimethylprostaglandins

✍ O.G. Plantema; H. de Koning; H.O. Huisman 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 182 KB

Synthesis of 10,10-dimethylprostaglandin

Synthesis of 10,10-dimethylprostaglandin E1

✍ O.G. Plantema; H. de Koning; H.O. Huisman 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 185 KB

The synthesis of 8-methyl-PGC22 and 12-methyl-PGAa3 and -PGE24 has been described recently. Degradation to biological inactive PGB-derivatives 1s lmpossible in these compounds. We now wish to report the synthesis of the lO,lO-dimethyl-PGEl analog A, which cannot be deactivated easily by transformat