Synthesis of 8-azaprostaglandin E1 and E2
β Scribed by J.W. Bruin; H. de Koning; H.O. Huisman
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 162 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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Interest in the unique biological properties 2) of 8-iso-prostaglandin (PG) El (1), which has been isolated by Daniels et al. in the biochemical transformation of 8,11,14-eicosatrienoic acid 3) , prompted us to synthesize a series of 8-iso-prostanoids. As the reported syntheses 4-6) of 1. have not
Solutions of (4j in organic solvents display an intensive blue fluorescence and in aqueous mineral acids a blue-green fluorescence. In the N M R spectrum (CDC13) a singlet occurs at T = 0.87, which is ascribed to the protons H-1 and H-3 (the neighboring protons to the ring nitrogen); the remaining p