Synthesis of (1, 2-13C2) 2-phosphoglycolic acid
โ Scribed by Edward J. O'Connor; York Tomita; Ann E. McDermott
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 223 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
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โฆ Synopsis
Abstract
The synthesis of (1,2โ ^13^C~2~) 2โphosphoglycelic acid, 5, from commerciallyโavailable (1,2โ ^13^C~2~) bromoacetic acid is described along with some of its solution NMR characteristics.
๐ SIMILAR VOLUMES
## Abstract The synthesis of (2,3โ^13^C~2~) erucic acid, for use in metabolic studies, is reported. The synthesis employs a repeated 3 step reaction sequence using ^13^C labeled triethylphosphonoacetate to extend C~18:1~, oleyl alcohol, by 4 carbons. The starting alcohol is first oxidized with PCC
## Abstract 5โ[4,5โ^13^C~2~]โ and 5โ[1,5โ^13^C~2~]Aminolevulinic acid (ALA) have been synthesized by the Gabriel condensation of potassium phthalimide with ethyl bromo[1,2โ^13^C~2~]acetate (derived from [1,2โ^13^C~2~]acetic acid) or ethyl bromo[2โ^13^C]โacetate (derived from sodium [2โ^13^C]acetate
## Abstract Rhodiumโcatalyzed carbonylation of methanol at mild temperature and pressure has been developed for smallโ and largeโscale preparations of the carbon isotope isomers of acetic acid.
## Abstract The chemical synthesis of 99% enriched D(โ)โ[1,7โ^13^C~2~]shikimic acid from [1,2โ^13^C~2~]acetate in 25% overall yield is described. A twoโcarbon phosphonate synthon was prepared from [1,2โ^13^C~2~]acetate and used in the shikimate synthesis of Fleet and coworkers.
The syntheses of a-ketoC2-' 3C]glutaric acid and a-ketoC1,2-' 'Cl glutaric acid were each achieved from commercial "CH,I in 5 steps. CH,NO,, prepared in situ from "CH,I and AgNO,, was treated with magnesium methyl carbonate, followed by acidified methanol to give 0,N13CH,C0,CH3. Michael addition to