Synthesis of 1-13C-1-indanone and 2-13C-1,2,3,4-tetrahydroquinoline
β Scribed by R. E. Pickering; M. A. Wysocki; E. J. Eisenbraun
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 229 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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## Abstract [2β^13^C, 2β^14^C]2βAminoethanol hydrochloride was prepared in good yield from Na\*CN in a two step sequence by first converting the Na\*CN to OHCH~2~\*CN and then reducing the nitrile directly with a solution of boraneβtetrahydrofuran complex. The reaction procedure was simple and the
13 13 [2-C]cyclohexanone was synthesized through [ Clcyanation of cyclopentanone followed by acetylation, reduction and ring expansion. Treatment with cupric bromide/lithium bromide and dehydrobromination of the resulting labeled 1,6-dibromohexanone in a "one pot" procedure gave [2-13C]phenol.