## Abstract A fast and efficient route to ^32^P‐labeled intermediates on the purine biosynthetic pathway is described. Adenosine kinase catalyzes the phosphorylation of 5‐aminoimidazole‐4‐carboxamide ribonucleoside (AICARs) to give [^32^P]‐5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR). This
Synthesis and separation of tritium-labeled intermediates of the shikimate pathway
✍ Scribed by Richard I. Christopherson; John F. Morrison
- Book ID
- 115705795
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 637 KB
- Volume
- 220
- Category
- Article
- ISSN
- 0003-9861
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📜 SIMILAR VOLUMES
The synthesis of tritium-labelled misonidazole via the NaB3H4. reduction of 1-(3-methoxy-2~xopropyl) -2-nitro-1Himidazole is described. Purification of labelled misonidazole was accqlished by recrystallization. The purity of the labelled cmpund was verified by HPLC.
## Abstract Mazindol was labeled with tritium in the 6,9 positions in low yield starting with dimethyl phthalate‐3,6‐^3^H which was prepared by reduction of dimethyl 3‐chlorophthalate with tritium gas using 10% palladium on charcoal as a catalyst. The labeled dimethyl phathalate was hydrolisized wi
## Abstract Tritium‐labeled bilirubin with specific activities ranging from 6.8 to 8.8 Ci/mmol was prepared in a single step by reducing biliverdin dihydrochloride with sodium borotritide in ethanol. Copyright © 2008 John Wiley & Sons, Ltd.
## Abstract Tritium labeled zomepirac with a specific activity of 85 Ci/mol was prepared by selective alkylation of the penultimate desmethyl precursor using methyl iodide‐^3^H~3~. The alkylation reaction was explored using various bases and solvent media.