## Abstract Mazindol was labeled with tritium in the 6,9 positions in low yield starting with dimethyl phthalateβ3,6β^3^H which was prepared by reduction of dimethyl 3βchlorophthalate with tritium gas using 10% palladium on charcoal as a catalyst. The labeled dimethyl phathalate was hydrolisized wi
The synthesis of tritium-labeled misonidazole
β Scribed by Jerry L. Born; Brian R. Smith
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 182 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
The synthesis of tritium-labelled misonidazole via the NaB3H4. reduction of 1-(3-methoxy-2~xopropyl) -2-nitro-1Himidazole is described. Purification of labelled misonidazole was accqlished by recrystallization. The purity of the labelled cmpund was verified by HPLC.
π SIMILAR VOLUMES
## Abstract Tritiumβlabeled bilirubin with specific activities ranging from 6.8 to 8.8βCi/mmol was prepared in a single step by reducing biliverdin dihydrochloride with sodium borotritide in ethanol. Copyright Β© 2008 John Wiley & Sons, Ltd.
## Abstract Tritium labeled zomepirac with a specific activity of 85 Ci/mol was prepared by selective alkylation of the penultimate desmethyl precursor using methyl iodideβ^3^H~3~. The alkylation reaction was explored using various bases and solvent media.
The synt esis of 3H-labelled azidothymidine (AZT) from accomplished by column chromatography. The purity of the labelled compound was determined by high performance 1 iquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.