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Synthesis and purification of carbon-14 labelled 1, 1-hexamethylene-bis [5-(4-chlorophenyl)biguanide] (chlorhexidine), ‘Hibitane’

✍ Scribed by J. Burns

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
425 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two syntheses of [^14^C] chlorhexidine (‘Hibitane’) with the label specifically incorporated in two separate molecular positions are described. Ring labelled chlorhexidine prepared from p‐chloro[U‐14C]aniline was obtained with a molar specific activity of 27.9 mCi/mmol. Chain labelled material, where the ^14^C label was incorporated in the 1 and 6 positions of the hexamethylene bridge, was prepared from [1, 6 ^14^C]‐adiponitrile, with a molar specific activity of 11.5 mCi/mmol. Several methods of purification are described.

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