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Synthesis of carbon-14 and carbon-13 labelled (R)-(−)-2[[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol

✍ Scribed by M. J. Ackland; M. R. Howard; E. J. Jacobsen; S. L. Secreast; L. G. Dring

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
597 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[^14^C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[^13^C~2~]‐pyrimidinyl)‐1‐ piperazinyl]‐[^13^C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[^13^C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐^13^C]‐carboxylic acid), [2,5‐^13^C~2~]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐^13^C~2~]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐^13^C~2~]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐^13^C~2~]‐ pyrimidine.

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