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Synthesis of carbon-14 and carbon-13 labeled 3-methyl-6-[3-(trifluoro-methyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

✍ Scribed by M. K. May; A. E. Lanzilotti

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
178 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

%Methyl -6-[3-( t r i f 1 uoromethyl ) phenyl 1-1,2,4-triazolo[4,3-b] p y r i d a z i n e ($), c u r r e n t l y being evaluated as a p o t e n t i a l anxiol y t i c agent was synthesized, l a b e l e d w i t h carbon-14 i n the 3p o s i t i o n o f t h e t r i a z o l o nucleus. i n 67% radiochemical y i e l d w i t h s p e c i f i c a c t i v i t y o f 13.5 mCi/mmol and r a d i o p u r i t y of g r e a t e r than 99%. The carbon-13 l a b e l e d compound was a l s o synthesized f o r absorption and metabolism studies.

The product was obtained Key Words : 3-Methyl -6-[3-( t r i f 1 uorome t h y l ) p he n y l ]-1 ,2,4tri azol o[ 4,3-b] pyridazine, A n x i o l y t i c Agent,

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