𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of carbon-14 labelled 1-[4-methyl-3-mxo-4-AZA-5α-androstane-17β-carbonyl]-1,3-diisopropylurea (turosteride), a new 5α-reductase inhibitor

✍ Scribed by E. Fontana; P. Angiuli; A. Pignatti; A. Panzeri; P. Dostert

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
295 KB
Volume
38
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

The synthesis in eight steps of the title compound from the commercially available[2O-"C]pregnenolone 1 is described.

The expected I-[4-methyl-3-oxo-4-aza-5a-androstane-17~-[14C]carbonyl]-1,3-diisopropylurea ([14C]FCE 26073) was

obtained with a radiochemical purity higher than 97% and a specific activity of 2.03 GBq/mmol. An overall radiochemical yield of21% was achieved from 1.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Concise Route to
ChemInform Abstract: A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. Part 3. Synthesis of (+)-19-Nor-10-azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one.
✍ A. GUARNA; E. G. OCCHIATO; F. MACHETTI; D. SCARPI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB

A Concise Route to 19-Nor-10-azasteroids, a New Class of Steroid 5α-Reductase Inhibitors. Part 3. Synthesis of (+)-19-Nor-10azatestosterone and (+)-17β-(Acetyloxy)-(5β)-10-azaestr-1-en-3-one. -The title compounds are of interest, since 5α-reductase inhibitors (by reducing the level of dihydrotesto