Synthesis of carbon-14 labelled cis-malonato [(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane] platinum(II) (ski 2053R)

✍ Scribed by Dae-Kee Kim; Youngseok Kim; Jonggill Rim; Ganghyeok Kim; Jongsik Gam; Sungkun Song; Kwanghee Yoo; Key H. Kim

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 448 KB
• Volume: 34
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580340208

✦ Synopsis

Abstract

The synthesis of ^14^C‐labelled cis‐malonato[(4__R__,5__R__)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐^14^C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.