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Synthesis and purification of [2-13C]-5-fluorouracil

✍ Scribed by Huzaifa S. Rangwala; John W. Giraldes; Vadim J. Gurvich

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
159 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[2‐^13^C]‐5‐Fluoropyrimidine‐2,4(__1__H,__3__H)‐dione ([2‐^13^C]‐5‐fluorouracil or [2‐^13^C]‐5‐FU) is a potential diagnostic agent for measuring 5‐FU‐induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of>99% on a multigram scale in a two‐step synthesis from [^13^C]‐urea. Preparative separation of [2‐^13^C]‐FU and [2‐^13^C]‐uracil was carried out by automated medium pressure silica gel column chromatography. The method is applicable to a broader range of 5‐FU isotopic analogs derived from labeled uracil. Copyright © 2011 John Wiley & Sons, Ltd.

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