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Synthesis and purification of 13C labelled xanthine derivatives

✍ Scribed by M. S. Boukraa; D. Deruaz; A. Bannier; M. Desage; J. L. Brazier

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
547 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

3‐[Methyl‐^13^C]xanthine, 7‐[Methyl‐^13^C]xanthe, 1,3‐[Dimethyl‐^13^C~2~]xanthine (theophylline‐1,3‐[^13^CH~3~]~2~), 1,7‐[Dimethyl‐^13^C~2~]xanthine (paraxanthine‐1,7‐[^13^CH~3~]~2~), and 3,7‐[Dimethyl‐^13^C~2~]xanthine (theobromine‐3,7‐[^13^CH~3~]~2~) were synthesized by nucleophilic substitution reaction (SN~2~) from xanthine (X) and iodomethane‐[^13^C]. The 3‐isobutylparaxanthine‐7‐[^13^CH~3~] was prepared from 3‐isobutyl‐1‐methylxanthine (IBMX). The compounds were purified by reverse phase semipreparative liquid chromatography and their chemical structure and purity verified by GC‐MS.

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