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Synthesis and protein kinase C inhibitory activities of indane analogs of balanol

โœ Scribed by Hong Hu; Sean P. Hollinshead; Steven E. Hall; Kiyomi Kalter; Lawrence M. Ballas

Book ID
103983388
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
298 KB
Volume
6
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES

Protein kinase C inhibitory activities o
Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements
โœ Julia M. Heerding; John W. Lampe; James W. Darges; Mark L. Stamper ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 255 KB

A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa < 7.6) display potent PKC activity, and show selectivity

ChemInform Abstract: Synthesis and Prote
ChemInform Abstract: Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogues That are Highly Selective for Protein Kinase C Over Protein Kinase A.
โœ J. M. DEFAUW; M. M. MURPHY; G. E. JUN. JAGDMANN; H. HU; J. W. LAMPE; S. P. HOLLI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i