Synthesis and Protein Kinase C Inhibitory Activities of Balanol Analogs with Replacement of the Perhydroazepine Moiety 1
✍ Scribed by Lai, Yen-Shi; Mendoza, José S.; Jagdmann, G. Erik; Menaldino, David S.; Biggers, Christopher K.; Heerding, Julia M.; Wilson, Joseph W.; Hall, Steven E.; Jiang, Jack B.; Janzen, William P.; Ballas, Lawrence M.
- Book ID
- 121430354
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 476 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa < 7.6) display potent PKC activity, and show selectivity
A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i