𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Protein Kinase C Inhibitory Activities of Balanol Analogs with Replacement of the Perhydroazepine Moiety 1

✍ Scribed by Lai, Yen-Shi; Mendoza, José S.; Jagdmann, G. Erik; Menaldino, David S.; Biggers, Christopher K.; Heerding, Julia M.; Wilson, Joseph W.; Hall, Steven E.; Jiang, Jack B.; Janzen, William P.; Ballas, Lawrence M.


Book ID
121430354
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
476 KB
Volume
40
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Protein kinase C inhibitory activities o
✍ Julia M. Heerding; John W. Lampe; James W. Darges; Mark L. Stamper 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 255 KB

A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa < 7.6) display potent PKC activity, and show selectivity

ChemInform Abstract: Synthesis and Prote
✍ J. M. DEFAUW; M. M. MURPHY; G. E. JUN. JAGDMANN; H. HU; J. W. LAMPE; S. P. HOLLI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i