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Synthesis and protein kinase C inhibitory activities of balanol analogues with modification of 4-hydroxybenzamido moiety

โœ Scribed by Hong Hu; Jose S. Mendoza; Christopher T. Lowden; Lawrence M. Ballas; William P. Janzen


Book ID
108480597
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
952 KB
Volume
5
Category
Article
ISSN
0968-0896

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ChemInform Abstract: Synthesis and Prote
โœ J. M. DEFAUW; M. M. MURPHY; G. E. JUN. JAGDMANN; H. HU; J. W. LAMPE; S. P. HOLLI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i