A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i
Synthesis and Protein Kinase C Inhibitory Activities of Acyclic Balanol Analogs That Are Highly Selective for Protein Kinase C over Protein Kinase A
✍ Scribed by Defauw, Jean M.; Murphy, Marcia M.; Jagdmann, G. Erik; Hu, Hong; Lampe, John W.; Hollinshead, Sean P.; Mitchell, Thomas J.; Crane, Heidi M.; Heerding, Julia M.; Mendoza, José S.; Davis, Jefferson E.; Darges, James W.; Hubbard, Frederick R.; Hall, Steven E.
- Book ID
- 121455909
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 397 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2623
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