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Synthesis and PKC inhibitory activities of balanol analogs with a cyclopentane substructure

✍ Scribed by Yen-Shi Lai; JoséS. Mendoza; Fred Hubbard; Kiyomi Kalter


Book ID
108038887
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
260 KB
Volume
5
Category
Article
ISSN
0960-894X

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📜 SIMILAR VOLUMES


Novel PKC inhibitory analogs of balanol
✍ G. Erik Jagdmann Jr.; Jean M. Defauw; Yen-Shi Lai; Heidi M. Crane; Steven E. Hal 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 236 KB

Balanol ((-)-!) is a potent protein kinase inhibitory natural product isolated from the fungus Vertici/lium ba/anoides. The presence of an ester functionality in this molecule has prompted concern over the metabolic stability of balanol, and has led to a search for active analogs lacking this moiety