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Synthesis and properties of cationic 2′-O-[N-(4-aminobutyl)carbamoyl] modified oligonucleotides

✍ Scribed by Kohji Seio; Munefumi Tokugawa; Takashi Kanamori; Hirosuke Tsunoda; Akihiro Ohkubo; Mitsuo Sekine


Book ID
113496691
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
639 KB
Volume
22
Category
Article
ISSN
0960-894X

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The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleoti