The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleoti
✦ LIBER ✦
Synthesis and properties of 2′-O-neopentyl modified oligonucleotides
✍ Scribed by Mathis, Gérald; Bourg, Stéphane; Aci-Sèche, Samia; Truffert, Jean-Christophe; Asseline, Ulysse
- Book ID
- 118739300
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 436 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1477-0520
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