𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and properties of oligonucleotides modified with 2′-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives

✍ Scribed by Yamada, Takeshi; Masaki, Yoshiaki; Okaniwa, Natsuki; Kanamori, Takashi; Ohkubo, Akihiro; Tsunoda, Hirosuke; Seio, Kohji; Sekine, Mitsuo

Book ID
125815014
Publisher
Royal Society of Chemistry
Year
2014
Tongue
English
Weight
701 KB
Volume
12
Category
Article
ISSN
1477-0520

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis, hybridization, and nuclease r
Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl (2′-O-AOE) modified oligonucleotides
✍ Andrew M. Kawasaki; Martin D. Casper; Thazha P. Prakash; Sheri Manalili; Henri S 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 221 KB

The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleoti