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Synthesis and in vivo evaluation of [11C]methyl-Ro 64-6198 as an ORL1 receptor imaging agent

✍ Scribed by Mikako Ogawa; Kentaro Hatano; Yasuhiro Kawasumi; Jürgen Wichmann; Kengo Ito


Book ID
117687766
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
120 KB
Volume
28
Category
Article
ISSN
0969-8051

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## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor