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Synthesis and in vivo evaluation of (E)-N-[11C]Methyl-4- (3-pyridinyl)-3-butene-1-amine ([11C]metanicotine) as a nicotinic receptor radioligand

✍ Scribed by Clive Brown-Proctor; Scott E Snyder; Phillip S Sherman; Michael R Kilbourn

Book ID: 117687591
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 224 KB
Volume: 27
Category: Article
ISSN: 0969-8051
DOI: 10.1016/s0969-8051(00)00091-3

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## Abstract Two novel ligands for cerebral cannabinoid receptor (CB1), 1‐(2,4‐dichlorophenyl)‐4‐cyano‐5‐(4‐methoxyphenyl)‐__N__‐(piperidin‐1‐yl)‐1__H__‐pyrazole‐3‐carboxamide (JHU75528) and 1‐(2‐bromophenyl)‐4‐cyano‐5‐(4‐methoxyphenyl)‐__N__‐(piperidin‐1‐yl)‐1__H__‐pyrazole‐3‐carboxamide (JHU75575)