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Synthesis and evaluation of 6-[11C]Methoxy-3-[2- [1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole as an in vivo radioligand for acetylcholinesterase

✍ Scribed by Clive Brown-Proctor; Scott E. Snyder; Phillip S. Sherman; Michael R. Kilbourn

Book ID: 117688327
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 292 KB
Volume: 26
Category: Article
ISSN: 0969-8051
DOI: 10.1016/s0969-8051(98)00078-x

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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)