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Synthesis and In-Vivo Evaluation of [ 11 C] p -PVP-MEMA as a PET Radioligand for Imaging Nicotinic Receptors

✍ Scribed by Dollé, Frédéric; Langle, Sandrine; Roger, Gaëlle; Fulton, Roger R.; Lagnel-de Bruin, Béatrice; Henderson, David J.; Hinnen, Françoise; Paine, Taliesha; Coster, Mark J.; Valette, Heric; Bottlaender, Michel; Kassiou, Michael

Book ID: 120448281
Publisher: Commonwealth Scientific and Industrial Research Organisation Publishing
Year: 2008
Tongue: English
Weight: 329 KB
Volume: 61
Category: Article
ISSN: 0004-9425
DOI: 10.1071/CH08083

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ABT-418 ((S)-3-methyl-5-[l-methyl-2-pyrrolidinyl]isoxazole) and N-methylcytisine (N-methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido-[ I,2-a][ 1,5]diazocin-8-one) are two high affinity nicotinic cholinergic agonists. ABT-418 was synthesized in 7 steps from commercially available (S)-Boc-proline in