Synthesis of 11C-labeled ORL1 receptor imaging agents, with [11C]ethyl iodide and [11C]methyl iodide
โ Scribed by M. Ogawa; K. Hatano; Y. Kawasumi; K. Ishiwata; K. Kawamura; S. Ozaki; K. Ito
- Book ID
- 112132900
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 145 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Toluene derivatives are often found in drugโlike molecules, and are therefore desirable as radiolabelled moieties. The desire for an alternate to the Stille coupling led us to investigate the feasibility of the Suzuki coupling. We have found the Suzuki coupling route to be a robust alte
## Abstract A method is presented for preparing [1โ^11^C]ethyl iodide from [^11^C]carbon monoxide. The method utilizes methyl iodide and [^11^C]carbon monoxide in a palladiumโmediated carbonylation reaction to form a mixture of [1โ^11^C]acetic acid and [1โ^11^C]methyl acetate. The acetates are redu