## Abstract Toluene derivatives are often found in drug‐like molecules, and are therefore desirable as radiolabelled moieties. The desire for an alternate to the Stille coupling led us to investigate the feasibility of the Suzuki coupling. We have found the Suzuki coupling route to be a robust alte
Synthesis of methyl iodide-11C and formaldehyde-11C
✍ Scribed by Christian Marazano; Mariannick Maziere; Gérard Berger; Dominique Comar
- Publisher
- Elsevier Science
- Year
- 1977
- Weight
- 259 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0020-708X
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A method and an apparatus for preparing [ 11 C]methyl iodide from [ 11 C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [ 11 C
## Abstract 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐[__methyl__‐^11^C]thymine ([^11^C]FMAU) [^11^C]‐**1** was synthesised __via__ a palladium‐mediated Stille coupling reaction of 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐5‐(trimethylstannyl)uracil **2** with [^11^C]methyl iodide in a