[11C]methyl iodide from [11C]methane and iodine using a non-thermal plasma method

✍ Scribed by Jonas Eriksson; Johan Ulin; Bengt Långström

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: French
• Weight: 137 KB
• Volume: 49
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.1135

✦ Synopsis

A method and an apparatus for preparing [ 11 C]methyl iodide from [ 11 C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [ 11 C]methane used in the experiments was produced from [ 11 C]carbon dioxide via reduction with hydrogen over nickel. [ 11 C]methyl iodide was obtained with a specific radioactivity of 412 AE 32 GBq/mmol within 6 min from approximately 24 GBq of [ 11 C]carbon dioxide. The decay corrected radiochemical yield was 13 AE 3% based on [ 11 C]carbon dioxide at start of synthesis. [ 11 C]Flumazenil was synthesized via a N-alkylation with the prepared [ 11 C]methyl iodide.