## Abstract Toluene derivatives are often found in drug‐like molecules, and are therefore desirable as radiolabelled moieties. The desire for an alternate to the Stille coupling led us to investigate the feasibility of the Suzuki coupling. We have found the Suzuki coupling route to be a robust alte
11C–C bond formation by palladium-mediated cross-coupling of alkenylzirconocenes with [11C]methyl iodide
✍ Scribed by Frank R. Wuest; Mathias Berndt
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 125 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2135
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## Abstract 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐[__methyl__‐^11^C]thymine ([^11^C]FMAU) [^11^C]‐**1** was synthesised __via__ a palladium‐mediated Stille coupling reaction of 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐5‐(trimethylstannyl)uracil **2** with [^11^C]methyl iodide in a
## Abstract The synthesis of a ^11^C‐labelled methyl stannane, (5‐[^11^C]methyl‐1‐aza‐5‐stanna‐bicyclo[3.3.3]undecane (**2**)), and its use in palladium‐mediated Stille reactions to form [^11^C]C–C bonds are described. Stannane **2** was synthesized from iodo[^11^C]methane, 5‐chloro‐1‐aza‐5‐stanna‐