## Abstract Toluene derivatives are often found in drug‐like molecules, and are therefore desirable as radiolabelled moieties. The desire for an alternate to the Stille coupling led us to investigate the feasibility of the Suzuki coupling. We have found the Suzuki coupling route to be a robust alte
An improved synthesis of [ 11 C]MENET via Suzuki coupling with [ 11 C]methyl iodide
✍ Scribed by Zeng, Fanxing; Voll, Ronald J.; Crowe, Ronald J.; Waldrep, Michael S.; Dolph, Karen B.; Goodman, Mark M.
- Book ID
- 125950546
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- French
- Weight
- 301 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-2135
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## Abstract 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐[__methyl__‐^11^C]thymine ([^11^C]FMAU) [^11^C]‐**1** was synthesised __via__ a palladium‐mediated Stille coupling reaction of 1‐(2′‐deoxy‐2′‐fluoro‐__β__‐D‐arabinofuranosyl)‐5‐(trimethylstannyl)uracil **2** with [^11^C]methyl iodide in a
An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid