𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An improved synthesis of (3-N-[11C]methyl)spiperone

✍ Scribed by Robert F. Dannals; Hayden T. Ravert; Alan A. Wilson; Henry N. Wagner Jr

Book ID
103919631
Publisher
Elsevier Science
Year
1986
Weight
154 KB
Volume
37
Category
Article
ISSN
0883-2889

No coin nor oath required. For personal study only.

✦ Synopsis

An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCi/mumol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

πŸ“œ SIMILAR VOLUMES

An improved synthesis of substituted [11
An improved synthesis of substituted [11C]toluenes via Suzuki coupling with [11C]methyl iodide
✍ Eric D. Hostetler; Garth E. Terry; H. Donald Burns πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 French βš– 92 KB

## Abstract Toluene derivatives are often found in drug‐like molecules, and are therefore desirable as radiolabelled moieties. The desire for an alternate to the Stille coupling led us to investigate the feasibility of the Suzuki coupling. We have found the Suzuki coupling route to be a robust alte

An improved synthesis of methyl propiola
An improved synthesis of methyl propiolate-1,2,3-13c3
✍ Daniel F. Lieberman; Sun-Shine Yuan πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 French βš– 190 KB

## Abstract An high yield synthesis of the title compound from ^13^CO~2~ is described. A key to the success is direct formation of the ester from the intermediate lithium propiolate‐^13^C~3~.