Recently, we reported the bioisosteric substitution of a guanidine by an acylguanidine entity in argininamide-type neuropeptide Y (NPY) Y 1 receptor (Y 1 R) antagonists, such as BIBP 3226 [1] (1; Scheme 1), to be an effective strategy for the [a] Dr.
✦ LIBER ✦
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for σ receptors
✍ Scribed by Brian R. de Costa; Wayne D. Bowen; Susan B. Hellewell; J.Michael Walker; Andrew Thurkauf; Arthur E. Jacobson; Kenner C. Rice
- Book ID
- 115922494
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 543 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
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## Abstract [^3^H](+)‐cis‐N‐(2‐(4‐Azidophenyl)ethyl) ‐2′‐hydroxy‐2,6‐dimethyl‐6,7‐benzomorphan ([^3^H]1) ([^3^H](+)‐AZPH), a novel high affinity and high selectivity benzomorphan based photoaffinity label for sigma receptors was synthesized in 4 steps starting with optically pure (+)‐normetazocine