𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular imaging of σ receptors: synthesis and evaluation of the potent σ1selective radioligand [18F]fluspidine

✍ Scribed by Steffen Fischer; Christian Wiese; Eva Große Maestrup; Achim Hiller; Winnie Deuther-Conrad; Matthias Scheunemann; Dirk Schepmann; Jörg Steinbach; Bernhard Wünsch; Peter Brust

Publisher
Springer
Year
2010
Tongue
English
Weight
351 KB
Volume
38
Category
Article
ISSN
0340-6997

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and biological evaluation of a
Synthesis and biological evaluation of a radioiodinated spiropiperidine ligand as a potential σ1 receptor imaging agent
✍ Rui-Qin Chen; Yan Li; Qiu-Yan Zhang; Hong-Mei Jia; Winnie Deuther-Conrad; Dirk S 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 192 KB 👁 1 views

## Abstract We report the synthesis and evaluation of 1′‐(4‐[^125^I]iodobenzyl)‐3H‐spiro[isobenzofuran‐1,4′‐piperidine] ([^125^I]Spiro‐I) as a potential SPECT tracer for imaging of σ~1~ receptors. [^125^I]Spiro‐I was prepared in 55–65% isolated radiochemical yield, with radiochemical purity of >99%

Synthesis and evaluation of new 18F-labe
Synthesis and evaluation of new 18F-labelled thienylcyclohexylpiperidine (TCP) analogues as radioligands for the NMDA receptor-channel complex
✍ Yoshihiko Shibayama; Shigeki Sasaki; Urara Tomita; Toru Nishikawa; Minoru Maeda 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 729 KB

We have synthesized new fluorine-18 labelled derivatives of thienylcyclohexylpiperidine (TCP), a non-competitive antagonist of NMDA receptor, which binds to the phencyclidine (PCP) binding site located within the receptor-associated ion channel. The mesylate precursors for (1S\* ,Z\*)-2-(hydroxymeth