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[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors

✍ Scribed by Christiane Durieux; Pierre-Jean Corringer; Florence Bergeron; Bernard P. Roques


Book ID
115882602
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
181 KB
Volume
168
Category
Article
ISSN
0014-2999

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The new CCKB analog, Boc-Tyr (S0,H)-gNle-mGly-Trp-(NMe)-Nle-Asp-PheNHJBC 264) exhibited a high affinity (KI = 0.39 2 0.15 nM) and selectivity for central (B) versus peripheral (A) receptors (KI CCKAKI CCKB = 910) in the rat. In agreement with these binding studies, BC 264 was a t least 50 times more