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Synthesis and comparative evaluation of 4-oxa- and 4-aza-podophyllotoxins as antiproliferative microtubule destabilizing agents

✍ Scribed by Natalia B. Chernysheva; Dmitry V. Tsyganov; Alex A. Philchenkov; Michael P. Zavelevich; Alex S. Kiselyov; Roman V. Semenov; Marina N. Semenova; Victor V. Semenov

Book ID
113496672
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
475 KB
Volume
22
Category
Article
ISSN
0960-894X

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Synthesis and Biological Evaluation of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxins as Potential Anticancer Agents
✍ Pitta Bhaskar Reddy; Satyam Kumar Agrawal; Swaran Singh; Bilal A. Bhat; Ajit K. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐