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Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

✍ Scribed by Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan, M.V.P.S.; Adil, S.F.; Nayak, V. Lakshma; Ramakrishna, S.


Book ID
118167391
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
674 KB
Volume
23
Category
Article
ISSN
0960-894X

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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐