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ChemInform Abstract: New Podophyllotoxin Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxicity of 4β-O-Propenylpodophyllotoxin Ethers.

✍ Scribed by Yadagiri Bathini; Andrew Scholte; Sean Kelly; R. G. Micetich; Moshen Daneshtalab

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxins as Potential Anticancer Agents
✍ Pitta Bhaskar Reddy; Satyam Kumar Agrawal; Swaran Singh; Bilal A. Bhat; Ajit K. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐